Relationship of 99mtechnetium labelled macroaggregated albumin (99mTc-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT)
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چکیده
منابع مشابه
Relationship of 99mtechnetium labelled macroaggregated albumin (99mTc-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT)
BACKGROUND SIRT is an emerging treatment for liver tumours which relies on the selective uptake by tumour of 90Y microspheres following hepatic arterial injection. Response rates of around 90% are reported. Hepatic arterial injection of MAA gives an indication of the expected distribution of 90Y microspheres within the liver. This study sought to determine if the MAA scan could be predictive of...
متن کاملSelective Interarterial Radiation Therapy (SIRT) in Colorectal Liver Metastases: How Do We Monitor Response?
Radioembolisation is a way of providing targeted radiotherapy to colorectal liver metastases. Results are encouraging but there is still no standard method of assessing the response to treatment. This paper aims to review the current experience assessing response following radioembolisation. A literature review was undertaken detailing radioembolisation in the treatment of colorectal liver meta...
متن کاملQUANTITATIVE PRETREATMENT 99mTc-MAA SPECT/CT AND FDG PET/CT VOI ANALYSIS OF LIVER METASTASES: RELATIONSHIP WITH TREATMENT RESPONSE TO SIRT
PURPOSE: In this study, using quantitive VOI analysis, the percentage Tc-MAA uptake and SUVmax and mean values of liver metastases obtained prior to SIRT by means of Theraspheres were related to treatment response. METHODS: Pretreatment FDG PET/CT scans and Tc-MAA SPECT/CT scans as well as post-treatment FDG PET/CT scans were coregistered and spherical VOI’s drawn around FDG positive liver lesi...
متن کاملSelective Internal Radiation Therapy (SIRT) as Conversion Therapy for Unresectable Primary Liver Malignancies.
BACKGROUND Many patients with primary liver cancers are not candidates for surgery, and systemic therapies are seldom effective. Selective internal radiation therapy (SIRT) has been shown to obtain partial and even complete response in unresectable primary tumors. As a "side effect", SIRT can induce contra-lateral liver hypertrophy. Tumor response to SIRT can be sufficient to allow disengagemen...
متن کاملSze Microspheres : Known Proof of Effectiveness Y - Loaded 90 Based Dosimetry for Liver Cancer Treated Using −
1. Lam MGEH, Goris ML, Iagaru AH, Mittra ES, Louie JD, Sze DY. Prognostic utility of 90Y radioembolization dosimetry based on fusion 99mTc-macroaggregated albumin–99mTc-sulfur colloid SPECT. J Nucl Med. 2013;54:2055–2061. 2. Garin E, Lenoir L, Rolland Y, et al. 99mTc-MAA SPECT/CT based dosimetry accurately predicts tumour response and survival in HCC patients treated with 90Y-loaded glass micro...
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ژورنال
عنوان ژورنال: BMC Nuclear Medicine
سال: 2005
ISSN: 1471-2385
DOI: 10.1186/1471-2385-5-7